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NAPEPLD Antibody, Biotin conjugated

Datasheet
Code CSB-PA764247LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NAPEPLD Polyclonal antibody
Uniprot No.
Q6IQ20
Target Names
NAPEPLD
Alternative Names
C7orf18 antibody; DKFZp781D1098 antibody; FMP30 antibody; Mbldc1 antibody; N acyl phosphatidylethanolamine hydrolyzing phospholipase D antibody; N acyl phosphatidylethanolamine phospholipase D antibody; N-acyl phosphatidylethanolamine phospholipase D antibody; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D antibody; NAPE hydrolyzing phospholipase D antibody; NAPE-hydrolyzing phospholipase D antibody; NAPE-PLD antibody; NAPEP_HUMAN antibody; NAPEPLD antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D protein (1-200AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

NAPEPLD Antibodies

NAPEPLD Proteins

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Target Background

Function
D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs.
Gene References into Functions
  1. The AC genotype and C allele of NAPE-PLD rs12540583 locus are risk factors for schizophrenia. PMID: 29652995
  2. NAPE-PLD forms homodimers partly separated by an internal channel and uniquely adapted to associate with phospholipids. PMID: 25684574
  3. our results do not support a clear role of FAAH, CNR1 and NAPE-PLD in BD and lithium response. PMID: 24126189
  4. a major physiological role of NAPE-PLD PMID: 24018423
  5. The differential expression of NAPE-PLD and FAAH suggests that Anandamide could play an important role in the pathophysiology of preeclampsia. PMID: 23122699
  6. NAPE-PLD expression increase steadily after infancy, peaking in adulthood. PMID: 22827915
  7. The results of this study suggested that NAPEPLD was alterated in multip;e sclerosis. PMID: 21251115
  8. a common haplotype in NAPEPLD, an enzyme involved in endocannabinoid synthesis, was protective against obesity. PMID: 20885390
  9. Observational study of gene-disease association. (HuGE Navigator) PMID: 20885390
  10. During the menstrual cycle, NAPE-PLD immunoreactivity was down-regulated in the secretory epithelial gland compared to the proliferative epithelial gland and unaffected in the stroma. PMID: 20369362
  11. The human NAPE-PLD was activated by phosphatidylethanolamine and inhibited by the beta-lactamase substrate nitrocefin. PMID: 19715685

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Subcellular Location
Golgi apparatus membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Nucleus envelope. Nucleus, nucleoplasm.
Protein Families
NAPE-PLD family
Tissue Specificity
Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level).
Database Links

HGNC: 21683

OMIM: 612334

KEGG: hsa:222236

STRING: 9606.ENSP00000340093

UniGene: Hs.324271

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